MIGERGOT is a migraine medicine


A different delivery approach for preventing migraines

Ask your doctor if MIGERGOT is right for you.


Copay assistance is available on MIGERGOT

Eligible patients will pay as little as $0

A Different Delivery Approach for Preventing and Treating Migraines

MIGERGOT is administered rectally which can be beneficial for patients with excessive nausea or vomiting symptoms.

Prescription Medication

MIGERGOT is only available in the United States with a prescription from a Healthcare Provider.

Ask your doctor if MIGERGOT is right for you.

You may pay as little as $0

Horizon offers copay assistance on MIGERGOT.  Eligible patients will pay $0 for MIGERGOT.

Click here to learn more.


What is the most important information I should know about MIGERGOT® (ergotamine tartrate and caffeine suppositories)?
Serious and/or life-threatening reductions in blood flow to the brain or extremities have been reported due to interactions between the active ingredients in MIGERGOT (ergotamine tartrate and caffeine) and protease inhibitors and macrolide antibiotics. These medications should not be taken together.

Uses of MIGERGOT® (ergotamine tartrate and caffeine suppositories)

MIGERGOT is a prescription medicine used in adults for treating or preventing a migraine headache.   MIGERGOT is not a pain medicine and should not be used to treat other types of headaches.

 Do not take MIGERGOT if you:

  • Are taking certain anti-HIV medications known as protease inhibitors such as ritonavir, nelfinavir or indinavir
  • Are taking a macrolide antibiotic such as erythromycin, clarithromycin or troleandomycin
  • Are taking anti-fungal medications such as ketoconazole or itraconazole
  • Have high blood pressure or if you have any disease affecting your heart, arteries, or blood circulation
  • Have liver or kidney disease
  • Are allergic to any of the ingredients in MIGERGOT

How to take MIGERGOT:

  • MIGERGOT is a rectal suppository. Do not take MIGERGOT orally.
  • One suppository of MIGERGOT should be taken at the first sign of a migraine attack.   If you do not experience relief from the first dose, a second dose may be taken no sooner than 60 minutes after the first dose.
  • The use of MIGERGOT should not exceed dosing guidelines and should not be used on a daily basis.
    • Do not take more than 2 suppositories for any single migraine attack.
    • Do not take more than 5 suppositories during any 7-day period.

Contact your doctor immediately if you experience:

  • Numbness or tingling in the fingers or toes
  • Muscle pain in the arms and legs
  • Weakness in the legs
  • Chest pain
  • Temporary speeding or slowing of the heart rate
  • Swelling or itching

Other side effects of MIGERGOT may include nausea and vomiting, rectal or anal ulcer (from overuse of suppositories), sensation of tingling or limbs “falling asleep”, numbness, weakness, dizziness, swelling and itching. This is not a complete list of all possible side effects. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

This is the most important information to know about MIGERGOT. Ask your healthcare professional if you have any questions or want more information.

Please see the Prescribing Information, including Boxed Warning, for more information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call   1-800-FDA-1088.

MIG-P-1013 (09/2014)


  • MIGERGOT is a medicine for migraines that is administered as a rectal suppository.
  • Many migraine patients experience excessive nausea and vomiting during attacks, making it difficult to take any oral medication. In these cases, taking medicine through the rectal route may be an effective way to get relief.
  • MIGERGOT contains ergotamine tartrate and caffeine which are medicines that cause narrowing of the blood vessels in the brain.
  • You should take MIGERGOT as indicated by your healthcare professional.
  • MIGERGOT should be kept refrigerated (36° to 46°F).